Aprovel tab

Manufacturer

Sanofi-Synthelabo

Distributor

Zuellig Pharma

Contents

Irbesartan

Angiotensin II Antagonists

Indications

Essential hypertension. Treatment of diabetic nephropathy w/ elevated serum creatinine & proteinuria (> 300 mg/day) in patients w/ type 2 diabetes & hypertension.

Dosage

Initial & maintenance dose: 150 mg once daily. May be increased to 300 mg or other anti-hypertensive agents can be added. Hypertensive type 2 diabetic patients Initially, 150mg once daily, titrated up to 300mg once daily as preferred maintenance dose for treatment of renal disease. In vol depleted patients, correct prior to administration. Elderly > 75 yr & haemodialysis patients Consider initiating w/ 75 mg.

Contraindication

Pregnancy, lactation.

Precautions

Increased risk of severe hypotension in patients w/ renal artery stenosis. Periodic monitoring of K & serum creatinine in patients w/ renal impairment. Monitoring of serum K in patients suffering from heart failure. Patients w/ recent kidney transplantation, primary aldosteronism, aortic or mitral stenosis, obstructive hypertrophic cardiomyopathy, ischaemic cardiopathy or ischaemic cardiovascular disease.

Adverse Reactions

Dizziness, nausea, vomiting, fatigue, orthostatic hypotension & dizziness, musculoskeletal pain.

Drug Interaction

Increased hypotensive effect w/ other hypotensive agents. K supplements & K-sparing diuretics may lead to increases in serum K. Monitor for possible increase in serum conc of lithium. Attenuation of antihypertensive effect & increased risk of renal impairment when used w/ NSAIDs.

Packing/Presentation

150mg x 28's (RM115.7)

300mg x 28's (RM144.7)

Pregnancy Category

C; D in 2nd & 3rd trimesters