Hyzaar tab    B   

Manufacturer 

Merck Sharp & Dohme

Contents

Losartan K 50 mg, hydrochlorothiazide 12.5 mg 

MIMS Class

Diuretics

Angiotensin II Antagonists 

Indications   

Treatment of hypertension, for patients in whom combination therapy is appropriate. 

Dosage   

Fixed dose combination is not indicated for initial therapy. Usual starting & maintenance dose: 1 tab once daily. May be increased to 2 tab once daily or 1 tab of Fortzaar once daily. Max: 2 tab once daily or 1 tab of Fortzaar once daily.

ADMINISTRATION:

May be taken with or without food. 

Contraindication     

Hypersensitivity including hypersensitivity to other sulfonamide-derived drugs; anuria. When used during 2nd & 3rd trimesters, drugs that act directly on the renin-angiotensin system can cause foetal injury & death. Discontinue as soon as possible if pregnancy detected. 

Precautions  

Angioedema. Not recommended for hepatic impairment or severe renal impairment (CrCl ≤ (smaller than or equal to) 30 mL/min). Hypotension & changes in renal function including renal failure. Bilateral renal artery stenosis or stenosis of the artery to a solitary kidney. Vol depletion or electrolyte imbalance. Thiazide therapy may impair glucose tolerance, precipitate hyperuricemia &/or gout, increase cholesterol & triglyceride levels, decrease urinary Ca excretion; intermittent & slight increases in serum Ca may occur. Hypersensitivity reaction may occur w/ or w/o a history of allergy or bronchial asthma. Thiazides have also been reported to exacerbate or activate SLE. Should not be initiated in patients w/ intravascular vol-depletion (eg. those treated w/ high dose diuretics). Lactation. Childn. 

Adverse Reactions  

Dizziness. Adverse experiences limited to those previously reported w/ losartan K &/or hydrochlorothiazide. Hyperkalemia, elevations in ALT. Anaphylactic reactions, angioedema, vasculitis including Henoch-Schonlein purpura (rarely), hepatits (rarely), diarrhea, cough, urticaria. 

Drug Interaction  

Losartan: Rifampin, fluconazole, K-sparing diuretics, K supplements or salt substitutes containing K, indomethacin. Hydrochlorothiazide: alcohol, barbiturates, narcotics, antidiabetic drugs (oral agents & insulin), other antihypertensives, cholestyramine, colestipol, corticosteroids, ACTH, pressor amines (eg. adrenaline), skeletal muscle relaxants, nondepolarizing (eg. tubocurarine), lithium, NSAIDs. 

Packing/Presentation  

tab 30's  

Pregnancy Category

Not established

Additional Information

For more information, including Dosage & Administration, Precautions & Side Effects, please refer to full prescribing information.