Kerlone tab    B 

 

Manufacturer 

Sanofi-Synthelabo

 

Contents

Betaxolol HCl 

 

MIMS Class

Beta-Blockers 

 

Indications  

Hypertension; prophylaxis of exertional angina episodes. 

 

Dosage  

20 mg once daily.

 

ADMINISTRATION:

May be taken with or without food. 

 

Contraindication  

Severe forms of asthma & COPD; cardiac insufficiency not controlled w/ treatment; cardiogenic shock; 2nd or 3rd degree AV block if no pacemaker is present; Prinzmetal's angina (as monotherapy in its isolated/typical form); sinus node dysfunction (including SA block); bradycardia (< 45-50 beats/min); severe forms of Raynaud's phenomenon & peripheral arterial disorders; untreated pheochromocytoma; hypotension; use in combination w/ floctafenine & sultopride. Avoid use in combination w/ amiodarone, bepridil, diltiazem & verapamil. Lactation. Contraindicated in congenital galactosaemia, glucose/galactose malabsorption or lactase deficiency syndrome due to presence of lactose. 

 

Precautions  

Mild asthma or COPD; 1st degree AV block; cardiac insufficiency controlled w/ treatment (administer in very low doses & increase w/ strict monitoring); peripheral arterial disorders; diabetic patients prone to hypoglycemia; psoriasis; use in patients undergoing general anesth; thyrotoxicosis; childn; elderly. Avoid abrupt w/drawal esp in patients w/ coronary heart disease. Reduce dose if bradycardia occurs. Patient w/ risk of any severe anaphylactic reaction, particularly to floctafenine or in those receiving drug desensitization treatments. 

 

Adverse Reactions  

Asthenia, cool extremities, bradycardia (possible severe), GI disturbances, impotence, insomnia. Less frequently, slowing of the AV conduction or worsening of pre-existing AV block, cardiac insufficiency, bronchospasm, hypoglycaemia, Raynaud's syndrome, aggravation of pre-existing intermittent claudication, psoriasis-like rashes or psoriasis exacerbation. 

 

Drug Interaction

Use w/ floctafenine or sultopride is contraindicated. Also avoid use w/ amiodarone, bepridil, diltiazem & verapamil. Volatile halogenated anaesth; drugs which may cause torsades de pointes: class Ia & III antiarrhythmics, certain phenothiazine neuroleptics (chlorpromazine, cyamemazine, levomepromazine, thioridazine), benzamides (amisulpride, sulpiride, tiapride), butyrophenones (droperidol, haloperidol), other neuroleptics (pimozide), cisapride, diphemanil, erythromycin IV, halofantrine, mizolastine, moxifloxacin, pentamidine, spiramycin IV, vincamine IV; propafenone; baclofen; insulin & sulfonylurea antidiabetics; anticholinesterase agents; centrally acting antihypertensive agents; lidocaine IV; NSAIDs, Ca antagonists (dihydropyridine), imipramine antidepressants, mefloquine, dipyridamole IV, α-blockers for urological use, amifostine. 

 

Packing/Presentation  

tab

10mg x 28's

20mg x 28's

 

Pregnancy Category

C; D in 2nd & 3rd trimesters.