Amaryl tab    C   

   

Manufacturer 

Aventis Farma

  

Distributor 

Zuellig Pharma

  

Contents

Glimepiride 

 

MIMS Class

Oral Antidiabetic Agents 

 

Indications  

NIDDM, whenever blood sugar levels cannot be controlled adequately by diet, physical exercise & wt reduction alone. May be used in combination w/ an oral antidiabetic containing metformin or w/ insulin. 

 

Dosage    

Initially 1 mg once daily. Maintenance: 1-6 mg daily.

 

ADMINISTRATION: Should be taken with food (Take immediately before the 1st main meal of the day. Do not skip meals.). 

 

Contraindication    

Insulin-dependent (type 1) diabetes mellitus; diabetic ketoacidosis; diabetic precoma or coma; hypersensitivity to glimepiride or any of its excipients, other sulfonylureas or sulfonamides; serious renal or hepatic dysfunction; dialysis patients. Pregnancy, lactation. 

 

Precautions    

Regular monitoring of glucose levels in blood & urine. Milder or absent symptoms of hypoglycaemia eg. in patients w/ autonomic neuropathy or taking β-blockers, clonidine, reserpine, guanethidine or other sympatholytic drugs. Temporary changeover to insulin in exceptional stress situations (eg trauma, surgery, infections w/ fever). 

 

Adverse Reactions    

Hypoglycaemia; adrenergic counter-regulation; temporary visual impairment; GI symptoms. Rarely thrombopenia, haemolytic anaemia, erythrocytopenia, leucopenia, agranulocytosis. 

 

Drug Interaction    

Potentiation of the blood-sugar-lowering effect by insulin & other (oral) antidiabetics, ACE inhibitors, allopurinol, anabolic steroids & male sex hormones, azapropazone, chloramphenicol, coumarin derivatives, fibrates, fluoxetine, ifosfamide, MAOIs, miconazole, oxyphenbutazone, pentoxyphylline, probenecid, quinolones, salicylates, sulfonamides, tetracyclines. Weakening of the blood-sugar-lowering effect by acetazolamide, barbiturates, corticosteroids, diazoxide, diuretics, epinephrine & other sympathomimetic agents, glucagon, laxatives, (after protracted use), nicotinic acid (in high doses), oestrogens & progestogens, phenothiazines, phenytoin, rifampicin, thyroid hormones. 

 

Packing/Presentation  

1mg x 30's  

2mg x 30's  

3mg x 30's  

 

Pregnancy Category

C